Major: Biology and Mathematics
Faculty Mentor: Fr. Nicanor Austriaco O.P., Biology
Parkinson’s Disease (PD) is the second most common, incurable neurodegenerative disorder worldwide. PD patients have accumulations of abnormal proteins called Lewy Bodies (LBs) within their neurons that trigger cell death. Damaged and dead neurons lead to decline in dopamine levels, triggering the symptoms of Parkinson’s such as muscle stiffness, tremors, and slowed movement. Numerous studies have shown that the human protein, alpha-synuclein and Tau, are two major components of Lewy Bodies. To study the relationship between protein aggregation and cell death, I have created a system to co-overexpress human alpha-synuclein fused to GFP and human Tau fused to mCherry in the budding yeast, Saccharomyces.
4-22-2020 12:00 AM