Progress towards the Synthesis of Chiral Heterobiaryl Atropisomers via [2+2+2] Cyclotrimerization
Subject Area
Chemistry
Description
Patrick Asher ’23, Major: Chemistry
Riley Hughes ’23, Major: Biochemistry
Giancarlo Irizarry ’23, Major: Chemistry
Faculty Mentor: Dr. Seann Mulcahy, Chemistry and Biochemistry
A suite of novel, bio-inspired atropisomeric β-carbolines were modeled and their theoretical energetic barriers to rotation were calculated. A select group of these molecules were then synthesized both as a racemate and asymmetrically, in order to further investigate their physicochemical and stereochemical properties. Here we present a novel synthesis of chiral heterobiaryl atropisomers via [2+2+2] cyclotrimerization.
Publisher
Providence College
Date
4-26-2023
Type
Poster
Language
English
COinS
